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Telogen effluvium from rapid weight loss (up to 24%) is the likely cause

How often are you asked by patients about caring for their skin after rapid weight loss from GLP-1 agonists

Gastrointestinal side effects, particularly nausea and vomiting, may further compromise nutritional status by limiting food intake

Patients should follow their healthcare providers instructions for use and attend regular follow-up appointments to monitor progress and assess the need for continued treatment

Concrete examples of biased agonism that have clearly improved therapeutic outcomes include the development of -arrestinbiased angiotensin II receptor ligands (which showed reduced hypertension-related adverse effects in preclinical models) and carfentanil-class opioid analogs designed to preferentially engage G-protein over arrestin pathways, thereby reducing respiratory depression (Schmid et al., 2017)

Patients should verify these registrations before proceeding